Muscadines are native to eastern North America, from Delaware south throughout Florida and west to Kansas and Mexico. Muscadine Grape. The muscadine berries range from bronze to dark purple to black in color when ripe. They have skin sufficiently tough that eating the raw fruit often involves biting a small hole in the skin to suck out the pulp inside. Muscadines are not only eaten fresh, but also are used in making wine, juice, and jelly. As with all grapes, muscadines need full sun with good air drainage. Hardiness zones 6-10.