Tylecodons range from an inch to over 6 feet in height. Their deciduous succulent leaves arranged in a spiral manner, are produced during the Winter.
Some species of Tylecodon are attractive or intriguing enough to be popular among succulent collectors. Most species are poisonous, with cardiotoxic and cumulatively neurotoxic Bufadienolides, and must be kept away from animals. However, novices have been advised to take precautions against poisoning. For example, some experienced horticulturists wear gloves when handling the plants.