Melothria pendula or Creeping cucumber can easily be started from seed, but they may take time to germinate, anywhere from 2-6 weeks. Plant them in a location that that provides full sun or semi-shade, with ample room for the vine to crawl. Once planted ensure regular water and weed competition is kept at bay.
Be warned that as a deciduous perennial it will die down during winter, however in USDA Zone 9-11 the mature plant is cold hardy to at least 30F for a short time. Creeping cucumbers produce many yellow and orange flowers and are often used in landscapes. If grown in a pot, then regular watering is essential and during cold regions, bring them indoors for the winter. While the fruits of the creeping cucumber are edible and full of health benefits, it is not as productive as some other cucurbits. It can produce a fair amount of fruit, although the fruits remain quite small and the vines will only produce for a few weeks. The good part is that they keep producing over a longer time than most of the other cucumbers. The fruits contain an array of vitamins including vitamin B6 and vitamin C. They are also rich in dietary fiber and folates which both contribute towards good heart health. The fruits of the Melothria pendula also make an excellent pickling cucumber, can be used as an addition in salads, soups, or even made into a pickle relish.