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Psychotria carthagenensis is an evergreen shrub or small tree with a small but dense, flat-topped crown. Unlike other Psychotria species, it has been found to be devoid of alkaloids.

Similar plants:

• Notopleura uliginosa, Psychotria uliginosa ()
• Psychotria ankasensis (Psychotria)
• Psychotria capensis (Black Bird-Berry, Bird-Berry, Bastard Lemonwood, Lemon Bush)
• Psychotria dolichocalix (Wild coffee)
• Psychotria ipecacuanha, Cephaelis ipecacuanha (Ipecacuanha)
• Psychotria kirkii (Psychotria)
• Psychotria nervosa, Psychotria ligustrifolia, Psychotria lanceolata, Psychotria nervosa var. lanceolata, Psychotria portoricensis, Psychotria undata (Wild Coffee, Bahama Coffee, Seminole Balsamo)
• Psychotria poeppigiana (Hot Lips, Labios Ardientes)
• Psychotria sp. (Psychotria)
• Psychotria sulzneri, Psychotria tenuifolia (Dull Wild Coffee, Velvet-leaved Wild Coffee)