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Senecio medley-woodii is a branched shrub up to 2 m tall with thick, succulent, white-felted stems. The leaves are white-felted, obovate (egg-shaped) with margins entire to coarsely and irregularly toothed.

Plant in full sun to light shade in a well-drained soil and irrigate occasionally to very little. This plant is an interesting shrub that has remained evergreen for us but is noted as being drought deciduous.

Similar plants:

• Kleinia neriifolia, Senecio kleinia (Verode)
• Kleinia pendula, Senecio pendulus (Tapeworm Plant)
• Kleinia stapeliiformis, Senecio stapeliiformis (Pickle Plant)
• Pericallis x hybrida, Senecio cruentus, Senecio x hybrida (Florist's Cineraria)
• Roldana petasitis, Senecio petasitis (Velvet Groundsel, California Geranium)
• Senecio angulatus (Creeping Groundsel)
• Senecio articulatus, Kleinia articulata (Hot Dog Cactus, Candle Plant)
• Senecio barbertonicus (Barberton Groundsel, Succulent Bush Senecio)
• Senecio cineraria, Cineraria maritima, Jacobaea maritima (Dusty Miller, Silver Ragwort)
• Senecio confusus, Pseudogynoxus confusus, Pseudogynoxus chenopodiodes (Mexican Flame Vine, Orangeglow Vine)