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Pedilanthus is very easy to grow as a houseplant. It needs some protection from hot summer sun, but it will be happiest in full sun during the fall and winter. Take care not to over-water, which can cause rotting. Water sparingly, just enough to make the potting mixture moist. Water even more sparingly if the room temperature is below 60 degrees; the temperature should never go below 55 degrees. Liquid fertilizer should be used once a month. Plant in well drained sandy mixture. It does best in a small pot; you can change pots to just one size larger when roots become extremely crowded. The sap is moderately caustic, although mild by Euphorbia standards, it should still be handled with caution.